The 49ers face the Titans at home in Santa Clara in Week 15. We break down what the game means for the NFL playoff picture.

Look back on our live updates of the 49ers-Cardinals game, which was played at the Cardinals' State Farm Stadium in Glendale, Arizona, on Sunday, Nov. 16. Arizona's Jacoby Brissett passed for more yards than any Cardinal since Kurt Warner, but it didn't ...

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

The Arizona Cardinals were beaten 41-22 by the San Francisco 49ers on Sunday at State Farm Stadium. A lot of thing went wrong. However, moving the ball offensively wasn't one of the problems. They had a season-high 488 yards of offense. They outgained the 49ers 488 to 281 in yards.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

Brock Purdy's return went as well as the San Francisco 49ers could have hoped, as they routed the Arizona Cardinals on Sunday.

The Arizona Cardinals (3-6) will host the San Francisco 49ers (6-4) at State Farm Stadium. Arizona is dealing with significant injuries, with 18 players listed on this week's injury report. San Francisco quarterback Brock Purdy is expected to return to the ...

Rookie Mike linebacker Cody Simon, playing instead of the injured Mack Wilson Sr., safeties Budda Baker and Jalen Thompson, and cornerback Max Melton played every snap. Rookie cornerback Denzel Burke missed six.

Eddy Piñeiro nears return, adding WR Javon Baker while releasing Matt Gay and Adrian Martinez to reshape depth.

Thanks to injuries, another team might be in the mix for a quarterback this offseason.

The San Francisco 49ers host the Tennessee Titans in Week 15 of the NFL season. Follow along for highlights and live score updates.