The San Francisco 49ers, led by quarterback Brock Purdy, face the Cleveland Browns, led by quarterback Shedeur Sanders, on Sunday, Nov. 30, 2025 at Huntington Bank Field in Cleveland, Ohio.

Let's say the 49ers lose in the first round of the playoffs, but it's a road game, and their offense scores more than 30 points while their defense is the reason they lose. In that case, the 49ers could blame the loss on the injuries to Bosa and Warner and feel good about themselves going into 2026 because those two will return.