A new reagent developed by chemistry professor Carolyn R. Bertozzi and coworkers at the University of California, Berkeley, eliminates the toxicity usually associated with a rapid and irreversible ...

The very high conversions reached by 'click' reactions under mild conditions make them very popular for modular syntheses — and none more so than the copper-catalysed azide–alkyne cycloaddition (CuAAC ...

The proposed platform for triple click chemistry has three functional groups that can be independently targeted for replacement by choosing an appropriate reaction partner. This platform is compatible ...

The Nobel Prize for Chemistry has been awarded to Carolyn Bertozzi, Morten Meldal and Barry Sharpless, the last of whom features in a group of only five to have won the Prize twice. The three chemists ...

The copper-catalyzed addition of azides and alkynes to form triazoles has been hailed as the crème de la crème of click chemistry—a way to assemble molecules via rapid, irreversible reactions. It is ...

‘Click chemistry’ wins the Nobel Prize in Chemistry for its ability to simply and reliably synthesize complex molecules and its application in living cells utilizing bioorthogonal reactions. Nature ...

Copper-free click chemistry has presented intriguing opportunities for the development of clickable drug surrogates, particularly in the context of fluorescent imaging of target of interest (TOI) ...