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What are CD4 T helper cells and why are they important?

Medically reviewed by Steffini Stalos, DO Key Takeaways CD4 T helper cells help the body fight infections by signaling other ...
The American Journal of Managed Care

Venetoclax May Restore Function in CD4 T Cells in CLL

Researchers of this new study found that treatment with venetoclax may be able to restore activation and proliferation of these cells, suggesting their plasticity can be leveraged for autologous ...
Science Daily

Dampening CD4+ immune cell function via the protein TLR4

The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages has ...
Nature

Effector and regulatory B cells: modulators of CD4 + T cell immunity

Clinical trial data have revealed that B cell depletion can be an effective therapy for a number of autoimmune diseases that are typically thought to be T cell dependent, such as type 1 diabetes, ...
Yahoo Finance

T-Cell Surface Glycoprotein CD4 Clinical Trial Analysis by DelveInsight

DelveInsight has recently added “T-cell Surface Glycoprotein CD4 – Pipeline Insight, 2020,” report to its store that provides detailed insights about 15+ companies and 15+ pipeline drugs in T-cell ...
EurekAlert!

Evolutionary conservation of CD4 and LAG-3 and their cytoplasmic tail motifs with opposing immune functions: do we finally understand LAG-3?

Conservation of their respective cytoplasmic tail motifs, CxC/H in the case of CD4 and an ITIM-like motif in the case of LAG-3, supports that competition between CD4 and LAG-3 for binding of kinase ...

WHO recommends CD4 testing to identify advanced HIV disease

CD4 tests are strongly recommended as the preferred method to identify advanced HIV disease among people living with HIV, the ...
JSTOR Daily

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4⁺ T cells

IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of ...
The New England Journal of Medicine

Regulation of Immune Responses by T Cells

The T-cell branch of the immune system can respond to a virtually infinite variety of antigens, in part because it includes a very large repertoire of T-cell clones, each with a unique receptor for ...
Aidsmap

Thyroid function of HIV patients should be checked; low CD4 count and d4T implicated

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Aidsmap

Nevirapine toxicity in women predicted by liver function, not CD4 count, developing country study reports

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