The illustration depicts how during differentiation cells normally lose their plasticity and ability to acquire new fates.

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

In recent years, the field of immunology has increasingly focused on the role of glycolipids and sphingolipids in the differentiation and function of innate immune cells, such as macrophages, ...

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

By recreating a fetal liver niche, FLOs show how liver and immune cells co-develop. Learn more about new groundbreaking ...

Descriptions of the embryo go back at least to the time of Aristotle, but it has only been since the late 19 th century and early 20 th century that advances in experimental approaches allowed ...

Functional analyses showcase that in the absence of IL-27, hematopoietic stem and progenitor cells are more likely to become monocytes during toxoplasmosis, making them less responsive after infection ...

Now, in a recently published Journal of Cell Biology paper, scientists used a newer electron microscopy technique, called volume electron microscopy (vEM), to examine how primary cilia on developing ...

Dlc1 deletion affects cardiac differentiation in mouse embryonic stem cells by activating the canonical Wnt pathway ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...