Tripartite motif–encoding proteins, or TRIMs, are a family of around 70 proteins in the human genome with an emerging role in innate immunity 1. They encode a tripartite motif comprising a RING domain ...
The inhibitors of cyclophilin A (CyPA) have drawn a great deal of attention due to their promising potential as small-molecule therapeutics for the treatment of cardiovascular diseases. This ...
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Wuhan, China, in December 2019 led to the novel coronavirus (CoV) disease 2019 (COVID-19), causing a ...
A new small molecule drug helps to bind the naturally occurring cellular chaperone cyclophilin A (CYPA) to the active state of the cancer-causing mutant KRAS G12C, disrupting oncogenic signaling and ...
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