This is the final article in this series discussing HPLC oligonucleotide separations. This article will discuss LC/MS analysis of failure sequences, phosphorothioate modified siRNAs, CpG methylated ...
HPLC is a widely used tool in peptide and protein purification. One of the challenges in this process is maximizing the lifetime of the bulk media sorbents or prepacked columns, which degrade due to ...
In the past few years, high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) has matured to a true alternative to antibody-based immunoassays in routine therapeutic drug ...
The author describes how liquid chromatography-mass spectrometry works and explains some of its advantages and disadvantages, particularly compared to high-performance liquid chromatography. Within ...
Operating HPLC at higher than ambient temperatures can improve peak shapes and enable faster run times. Preheating the mobile phase is significant in high temperature liquid chromatography as the ...
Chromatography is an analytical technique that is used to separate mixtures by distributing the components of a mixture between a stationary phase and a mobile phase. Columns are used in various types ...
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