From fast-food to ultra-processed snacks, a high-fat diet eaten over the long term may trigger biological changes in the ...

Scientists from Cincinnati Children's and colleagues based in Japan report achieving a major step forward in organoid technology: producing liver tissue that grows its own internal blood vessels. This ...

A modified pig liver transplanted into a human patient appears to have functioned normally for the duration of the investigation with no signs of rejection. For 10 days, the liver performed its basic ...

Long before a liver tumor appears, a high-fat diet can push liver cells into a risky survival mode. That is the central ...

A multidisciplinary team from China has successfully transplanted a gene-modified pig liver into a human recipient diagnosed with brain death. During a 10-day observation period, the porcine liver ...

Scientists have developed a functional human hepatic tissue in a mouse host. The human hepatic tissue, in the mice, is composed of human hepatocytes and non-parenchymal cells (NPCs) including human ...

A new drug combination shows unexpected synergy against liver fibrosis. A new study reveals that using two drugs together ...

Microfluidic chips that mimic human livers are better at predicting whether a drug is toxic to the liver than conventional animal models used in preclinical experimentations, claims a new study from ...

This article is based on a poster originally authored by L. Fäs, F. Wenz, M. Tu, K. Sanchez, N. Zapiórkowska-Blumer, H. Varga and K. Kaczmarska, which was presented at ELRIG Drug Discovery 2024 in ...

Of all the organs, the liver is most susceptible to drug toxicity. Drug-induced liver injury (DILI) is a leading cause of drug attrition, with over 750 FDA-approved drugs known to have a level of DILI ...