Andy Reid told reporters during his postgame news conference that Mahomes would have an MRI on his injured left knee by Monday. The 67-year-old sounded pessimistic when discussing the star quarterback's injury. "It didn’t look good," Reid said when asked about Mahomes' injury. "We'll just see where it goes."

Already, the Week 15 slate has a handful of clinching scenarios. The New England Patriots can clinch the AFC East title with a win over the Buffalo Bills on Sunday, while both the Denver Broncos and Los Angeles Rams can punch their tickets with wins.

Mahomes was injured as he was chased from behind and got tangled up with Chargers lineman Da’Shawn Hand. Mahomes immediately grabbed his knee after it buckled and eventually needed help from two Chiefs staffers to walk to the locker room. The Chiefs have three games remaining in the season.

Dr. Jesse Morse analyzed video of Patrick Mahomes' left knee hyperextension and stated there was “a little medial stress" to his MCL.

RB Josh Jacobs (knee) is expected to play Sunday against the Broncos, NFL Network Insiders Ian Rapoport and Tom Pelissero reported. RB  Christian McCaffrey  (back) should be good to go Sunday against the Titans despite being a late addition to the injury report, NFL Network Insider Ian Rapoport reported.

Quarterback Daniel Jones is reportedly expected to be back in time for the start of the 2026 NFL season, but his future with the Indianapolis Colts isn't yet certain.

Pittsburgh Steelers edge rusher T.J. Watt is dealing with a lung injury that led to his hospitalization. On Friday, NFL Network's Tom Pelissero offered more details about what's going on.

The Colts are looking to avoid becoming the 6th team since the 1970 Merger to miss the playoffs after starting 7-1 or better through 8 games (2012 Bears, 1996 Washington, 1988 Saints, 1987 Chargers, 1975 Dolphins) Lets take a deeper dive into this week’s matchup between the two teams seemingly headed in opposite directions.