Although previously thought to be neutral, research in yeast suggests that synonymous point mutations may have strongly nonneutral effects. A group of researchers from the University of Michigan (MI, ...

Since the genetic code was solved in the 1960s, synonymous mutations have been generally thought to be benign. We now show that this belief is false. Because many biological conclusions rely on the ...

Researchers are adding new evidence to the emerging concept that 'silent' or synonymous mutations may have crucial consequences. Their study showed how a synonymous mutation in one gene can ...

For example, there is a synonymous mutation in the chloride transmembrane cystic fibrosis transmembrane conductance regulator (CFTR) that slows down CFTR production and folding because it interacts ...

For example, synonymous mutations are generally ignored in the study of disease-causing mutations, but they might be an underappreciated and common mechanism." In the past decade, anecdotal evidence ...

Genes hold the recipe for proteins, which are made of amino acids. DNA only has four letters, or nucleotides, and each sequence of three nucleotide bases, or codon, encodes for one amino acid. There ...

New modeling shows how synonymous mutations—those that change the DNA sequence of a gene but not the sequence of the encoded protein—can still impact protein production and function. A team of ...

Synonymous or silent mutations do not change the sequence of the protein that they encode. With some exceptions, they do not trigger any effect. Last year, however, a study by researchers from the ...