A small-molecule ligand that binds to a (CAG) n hairpin repeat is the basis of a biosensor to detect repeat length, which may help diagnose trinucleotide repeat disease severity. DNA trinucleotide ...
When CAG nucleotide triplets repeat excessively in a gene called huntingtin, a devastating and currently untreatable neurodegenerative “repeat expansion disorder” arises called Huntington’s Disease ...
The inheritance of mutated version of either BRCA1 or BRCA2 confers a high risk of developing breast cancer. However, only 10-20 % of the breast cancer families carries BRCA mutations, suggesting the ...
Peter L. Salgo, MD: Hello, and thank you for joining this AJMC® Peer Exchange titled “A Closer Look at Rare Diseases: Spinal Muscular Atrophy and Huntington Disease.” With 250 diseases newly ...
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