Drugs currently marketed for pulmonary arterial hypertension have been able to extend the lives of patients but have shown limitations in their ability to prevent or reverse the disease. A novel ...

Peripheral vascular resistance has a fundamental role in controlling blood pressure. Peripheral vascular resistance depends directly on vascular tone that results from the balance between ...

Impaired vascular function leads to cardiovascular disease. Researchers have found that prolonged sitting impairs forearm cutaneous vasodilation function. They also showed that alternating local skin ...

Recent studies have suggested that contraction of the smooth muscle in the cavernosal arterioles and in the walls of the cavernosal sinuses is maintained by the RhoA/Rho-kinase signaling pathway.