Research shows how immune system reacts to pig kidney transplants in living patients

Novel research led by Brazilian scientists describes the immune system's reactions in detail in the first living patient to ...

MiNK Therapeutics and University of Wisconsin–Madison Announce Phase 1 Clinical Trial of Allo-iNKT Cell Therapy (AgenT-797) to Evaluate Prevention of Graft-Versus-Host Disease

Non-dilutive public-private funded trial with NIAID STTR & Mary Gooze Clinical Trial and Translation AwardExpands iNKT platform into ...

High glutamine levels suppress immune response in head and neck cancer tumors

A novel tumor suppressor, BATF2, can be silenced by factors in the tumor microenvironment, leading to a reduced immune ...
EurekAlert!

High levels of protein drive tumor immune suppression in head and neck cancer

BATF2 is a new type of tumor suppressor that can be epigenetically silenced by high levels of glutamine in the tumor microenvironment Glutamine silences BATF2 and leads to a weakened immune response ...
PNAS

Coordinated actions of NLR-assembled and glutamate receptor–like calcium channels in plant effector-triggered immunity

Contributed by Jane E. Parker; received April 9, 2025; accepted July 23, 2025; reviewed by S. P. Dinesh-Kumar, Brian J. Staskawicz, and Cyril Zipfel This contribution is part of the special series of ...
Gut

CD48 is a novel immune checkpoint on tumour‐associated macrophages in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...
Frontiers

SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer

Background: Serum amyloid A (SAA), an acute-phase pro-inflammatory protein, is overexpressed in several cancers and is involved in shaping pro-tumor responses. We have previously reported that lung ...