The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Glioblastoma (GBM) is one of the most common and aggressive primary brain tumors in adults, carrying an extremely poor ...

Scientists are searching for therapeutics that mimic the life-extending benefits of caloric restriction, exercise, and a good ...

Cancer researchers have long treated genetic chaos and epigenetic rewiring as separate engines of disease, two parallel hallmarks that help tumors grow, spread, and resist treatment. Now a new wave of ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment.

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation.