Comprehensive map reveals how E3 ligases organize protein cleanup in human cells

Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with ...

New ALS treatment target identified: STAUFEN-1 protein reduction protects brain cells from death

University of Utah researchers at the Pulst-Scoles Laboratory have discovered that reducing levels of the STAUFEN-1 protein ...

How major nuclear protein complexes control specialized gene regulation in cancer and beyond

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

I Went on a High-Protein Diet for 2 Weeks—Here’s How My Skin and Body Changed

According to experts, protein is essential for tissue repair, skin benefits, healthy aging, hormone balance, muscle ...

7 High-Protein Foods Highlighted in the New U.S. Dietary Guidelines

Healthy nuts such as walnuts, which contain 4g of protein per ounce, are also featured high up in the new food ...
GEN

“Human Domainome” Reveals Cause of Many Diseases

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...
News Medical

Most disease-causing mutations that swap amino acids do so by making proteins less stable

A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability In a recent study published in Nature, researchers used ...
News Medical

Human protein MxA restricts H5N1, but virus mutations raise alarms

Researchers uncover how a key human immune protein curbs H5N1 avian flu, but the virus is evolving—could we be on the brink of a new zoonotic threat? Research Letter: Replication Restriction of ...