Upadacitinib is not approved for pediatric IBD, though the selective JAK1 inhibitor is indicated for patients 2 years and older with juvenile idiopathic arthritis and psoriatic arthritis. The findings ...

Normally, PTPN2 helps maintain gut health by controlling inflammation and supporting a balanced gut microbiome. However, some ...

AGA clinical practice guidelines for inflammatory bowel disease management have undergone “major shifts” in recent years, placing diet front and center and urging patients to adhere to Mediterranean ...

The new molecules selectively reduced inflammatory signaling in human immune cells without affecting other immune pathways. Treatment with the molecules also reduced inflammation in mice with the ...

A healthy digestive tract is the key to good health. The digestive process is complex and the digestive tract is designed to ...

A chain of immune reactions in the gut—driven by a key signaling protein and a surge of white blood cells from the bone ...

A chain of immune reactions in the gut—driven by a key signaling protein and a surge of white blood cells from the bone marrow—may help explain why people with inflammatory bowel disease (IBD) have a ...

Higher total meat intake was associated with an increased risk of disease flare ups in ulcerative colitis, a prospective cohort study found. (Gut) The prevalence of chronic opioid use reached highs of ...

In the treatment of inflammatory bowel disease, synthetic mucus gels can be used to deliver monoclonal antibodies without inducing broad immunosuppression.

Regular stool tests already used in NHS care, combined with dietary information, could help identify people with inflammatory ...

Under healthy conditions, the intestinal epithelium fully renews itself every three to five days. Aging and exposure to ...