PEGASUS generates permeable macrocyclic peptides, offering new promise for a modality that can combine the properties of a biologic in a pill ...
A research team shows that small phenolic acids can dramatically enhance the activity of tetracycline against multidrug-resistant Escherichia coli.
It achieves AI-driven generative design of the first permeable macrocyclic peptide with more than two polar or ionizable fragments. -- Surrogate assays are a breakthrough for AI model training. 1910 ...
This is an important study on the sensory roles of Cerebrospinal fluid-contacting neurons (CBF-cn) in mammals. The authors identify PKD2L1 as the predominant pH-sensing channel CBF-cn and show how the ...
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