BioWorld

RNA-targeting CRISPR-Cas13 and engineered U1 correct variants in Stargardt disease

Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...
Health And Pharma

Rewiring RNA: Antisense RNA Therapy Exposes a New Weakness in Pancreatic Cancer

Researchers at CSH Laboratory identified an oncogenic SRSF1–AURKA–MYC circuit driving pancreatic ductal adenocarcinoma.
Fred Hutch

RNA “typos” can highlight leukemia cells for immune attack

Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...
AZoLifeSciences on MSN

Dual genetic mutations drive RNA mis-splicing and leukemia progression

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic ...
ALZFORUM

TDP-43 Missplicing: A Common Factor in Neurodegenerative Disease?

In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...