Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage ...

HP1γ interacts with TRIM66 through the PxVxL motif: Crystal structure analysis and binding affinity studies demonstrate a specific interaction between the chromo shadow domain (CSD) of HP1γ and the ...

Uveal melanoma is a type of cancer in a region of the eye called the uvea. It is typically treated with radiation, which cures about half of patients. However, half of the patients subsequently ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

For efficient transcription, RNA PolII must overcome the presence of nucleosomes. The p38‐related MAPK Hog1 is an important regulator of transcription upon osmostress in yeast and thereby it is ...

Muscle development and metabolic homeostasis are critical aspects of human health. As a key component of the SWI/SNF chromatin remodeling complex, the BAF60 subunit plays a widespread and crucial role ...

Chromatin remodelers are ATP-dependent motor proteins that dynamically reorganize chromatin architecture, playing essential roles in gene expression, development, and immune function. Dysregulation of ...

Dysregulated Wnt signaling is a well-established driver of colorectal carcinogenesis. However, its pivotal role in normal intestinal stem cell homeostasis has posed significant challenges for its ...

The Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex comprises 10-15 subunits, which modulate the arrangement, location, or conformation of nucleosomes to upregulate chromatin ...