Scientists can peer into cells to get a limited view of their activity using microscopes and other tools. However, cells and ...

Pretzel Therapeutics is advancing its mitochondrial disease therapies, pushing lead candidate PX578 through Phase 1 trials ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

Francis Crick missed a crucial seminar in 1951, probably because he was seeing a lover. James Watson did go, failed to take notes and misremembered key details. As a result, their first model of DNA ...

We know, based on abundant research, that physical activity is good for both physical and mental health, in terms of both preventing and helping to manage a long list of concerns. For example, ...

James D. Watson, whose co-discovery of the twisted-ladder structure of DNA in 1953 helped light the long fuse on a revolution in medicine, crimefighting, genealogy and ethics, has died, according to ...

James Watson, one of the discoverers of the structure of DNA, has died in a New York hospice facility at the age of 97. Along with fellow researchers Francis Crick and Maurice Wilkins, he won the 1962 ...

A woman eager to discover the true identity of her puppies’ father got more than she bargained for after having them undergo a DNA test. Pet DNA testing has never been more popular. In 2024, the ...

Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive tolerability profile, expected PK/PD activity, and promising clinical signals ...

Y-family DNA polymerases (Pols) are intrinsically highly error-prone; yet they conduct predominantly error-free translesion synthesis (TLS) in normal human cells. In response to DNA damage, Y-family ...

This study, conducted on maize seedlings, investigated how plants respond to excess copper at a molecular level Copper stress caused widespread changes in gene activity, altering over 3,300 genes, and ...