This is the final article in this series discussing HPLC oligonucleotide separations. This article will discuss LC/MS analysis of failure sequences, phosphorothioate modified siRNAs, CpG methylated ...

HPLC is a widely used tool in peptide and protein purification. One of the challenges in this process is maximizing the lifetime of the bulk media sorbents or prepacked columns, which degrade due to ...

This short seminar is suitable for all analysts working in HPLC/UHPLC and focuses on the preventable problems that commonly occur with LC columns. The course will help analysts to think about how they ...

In the past few years, high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) has matured to a true alternative to antibody-based immunoassays in routine therapeutic drug ...

The author describes how liquid chromatography-mass spectrometry works and explains some of its advantages and disadvantages, particularly compared to high-performance liquid chromatography. Within ...

High-performance liquid chromatography (HPLC) is an analytical chemistry technique used to separate liquid mixtures of compounds or analytes. The method employs a liquid "mobile phase" to transport ...

Chromatography is the backbone of analytical laboratories all over the globe with high performance liquid chromatography (HPLC) representing the largest portion. In HPLC, samples are dissolved in a ...

Polysaccharide-based chiral stationary phases have been developed that comprise chiral selectors immobilized on their support rather than being physically coated. These materials are completely ...

As you reach the end of the run and possibly the conclusion of the workday, you may wonder what to do with the column you have recently used. You might consider whether it should remain attached to ...