Chronic pain with a 30.3% global prevalence significantly impacts universal health. Low back pain has a 9.4% prevalence worldwide causing the most widespread disability. Neck pain ranks 4th highest ...

Management of adverse events is a major concern of clinicians who use antipsychotic drugs. The incidence of motor side effects is dose dependent. Atypical antipsychotic drugs are less likely to induce ...

Medizinische Klinik I, Ludwig-Maximilians-Universität München, FRG. Dose-response curves using the beta-adrenergic receptor agonists isoprenaline (no neuronal uptake) and epinephrine (neuronal uptake) ...

FAMILIAL dysautonomia is an inherited disease with a complex but fairly well defined symptomatology. Alacrima, postural hypotension, poor motor co-ordination and a relative indifference to pain are ...

A MECHANISM was recently proposed (personal communication from M. H. Seevers and ref. 1) whereby psychic dependence could arise because a drug tipped towards reward the balance of the linked reward ...

ABSTRACT: The use of gene therapy has been intensively studied as a potential method to treat Parkinson’s disease (PD) and other degenerative brain diseases. However, the effects of experimental ...

Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general ...

Dopamine (DA) neurons of the ventral tegmental area (VTA) are critical to limbic and cognitive functions, and, hence, exert a major impact on behavioral regulation. Consequently, their dysfunction is ...

The major advances in the area of movement disorders in Brazil in recent years were driven by the work of Luiz Augusto Franco de Andrade and Egberto Reis Barbosa. This historical review describes the ...

Dopamine supersensitivity psychosis (DSP) frequently arises with long-term antipsychotic treatment and accounts for a significant proportion of treatment-resistant schizophrenia. The mechanism ...

While the recreational use of cannabis has well-established dose-dependent effects on neurocognitive and psychomotor functioning, there is little consensus on the degree and duration of impairment ...

Abstract: It is well known that the migraine patients indicate abnormal information processing such as photic supersensitivity. And it is high incidence and an aggravation factor of migraine attack.