Advances in biofabrication and 3D in vitro model systems are transforming biomedical research, drug development, and toxicity testing. However, despite ...

Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...

Biological assailants like fungi, bacteria, and viruses continuously test natural defenses that have evolved over millennia. Newer and stranger particles that originate from burning fuels, harmful ...

When developing drugs, we rely on animal models to test drugs in an entire system before first-in-human studies. However, animals aren’t human and interspecies differences in pharmacology, physiology, ...

Well before a human receives the first dose of an experimental drug, it’s evaluated in an animal to test for toxicity. Monkeys are often chosen for their genetic similarities to humans, and safe ...

Traditional animal models and simplified cell cultures often fail to capture human biology, limiting progress in biomedical research and drug development. Emerging microfluidic "Organ-on-Chip" ...

For our Spotlight on patient-derived in vitro cell models, we surveyed our audience to find out the latest trends, opinions and behaviors in the field. This infographic summarizes the results from the ...

Overcoming acquired treatment resistance is one of the major challenges in the fight against cancer. While combination therapies hold promise, their toxicity to healthy tissue remains a major hurdle.

A small molecule known as 10H-phenothiazine reduced the loss of motor neurons, the nerve cells that are lost in SMA, in ...