A new study by Scripps Research reveals that alcohol dependence disrupts two signaling pathways in a stress-related part of the brain—and offers insights on developing drugs to treat this condition.

Orexin, one of the two signals the researchers studied, originates in neurons (green) in the brain’s hypothalamus (left) that connect with a part of the thalamus called the pPVT (right). LA JOLLA, ...

Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States Research Institute of Pharmaceutical Sciences, School of Pharmacy, ...

The review period has been extended by 90 days. The Food and Drug Administration (FDA) has extended the review period for elinzanetant, an investigational hormone-free therapy for the treatment of ...

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...

1 Nutrition, Growth and Physiology Research Unit, U.S. Meat Animal Research Center, Agricultural Research Service, United States Department of Agriculture, Clay Center, United States 2 Physiology ...

Summary: Researchers reveal how specific brain neurons impact ovarian function and hormone release, essential for reproduction. Kisspeptin neurons and dynorphin receptors play a crucial role in ...

NIH/NIDA IRP, Baltimore, Maryland 21224, Departments of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, Departments of Anatomy and Physiology and W.M.

The authors address the function of dorsal horn inhibitory neurons that express neuropeptide Y in adulthood. They find relevant functions in pain and itch control that should be of broad interest to ...

Boyle et al identify Npy-expressing dorsal horn neurons as powerfully inhibiting pain and itch under normal and pathological conditions. The valuable data are convincing, and the effect sizes are ...