MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses.

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a rare systemic autoimmune disease characterized by a clinically amyopathic …

Aug 2, 2025 · MDA5 is an interferon-inducible RNA helicase that plays a significant role in the innate immune system, detecting viral RNA and initiating antiviral responses. The presence of …

Dec 6, 2023 · Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis. Although the aetiology and …

MDA5 refers to a cytoplasmic RNA helicase encoded by the MDA5 gene, which is part of the RIG-I-like receptor family involved in the innate immune response against viruses, recognizing …

MDA5 deficiency is a disorder of the immune system (immunodeficiency) that leads to recurrent, severe infections of the lungs and airways (respiratory tract) beginning in infancy. These …

Anti-MDA5 dermatomyositis involves the production of autoantibodies against MDA5, a protein that helps detect viral infections. In this condition, the immune system mistakenly attacks …

May 5, 2025 · Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a rare systemic autoimmune disease characterized by a …

Sep 1, 2024 · Many of the cutaneous manifestations of anti-MDA5 antibody–positive DM (anti-MDA5-DM) are unique or atypical when compared to other IIM subtypes. This can have …

Nov 3, 2023 · By following a large cohort of patients who developed MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous with the COVID-19 Pandemic (MIP-C), this study …